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Publication

List of papers published

2024

1. Shukla A, Suresh V, Gupta PC, Sharma M, Saikia UN, Ram J Ram, Luthra-Guptasarma M. (2024) A single chain variable fragment antibody (Tn 64) cognate to fibronectin type III repeats promotes corneal wound healing by inhibiting fibrosis. Int Immunopharmacol 133:112029. doi: 10.1016/j.intimp.2024.112029.

2. Banerjee S, Radotra BD, Luthra-Guptasarma M. (2024) Identification of novel pathogenic variants of Calpain-3 gene in limb girdle muscular dystrophy R1. Orphanet J Rare Dis 19, 140.

3. Sharma S, Thakur AK, Sharma M, Katoch D, Bansal R, Singh R, Dogra MR, and Luthra-Guptasarma M. (2024) A simulacrum of Proliferative Vitreoretinopathy (PVR): Development and proteomics-based validation of an in vitro model. Journal of Proteins and Proteomics. https://doi.org/10.1007/s42485-024-00140-0.

4. Sharma M, Kaur S, Mavlankar NA, Chanda A, Gupta PC, Saikia UN, Ram J, Pal A, Mandal S, Guptasarma P, and Luthra-Guptasarma M. (2024) Use of discarded corneo-scleral rims to create cornea-like tissue. Molecular Biology Reports 51:391. https://doi.org/10.1007/s11033-024-09321-y.

2023

5. Mahintamani T, Basu D, Ghosh A, and Luthra-Guptasarma M. (2023) The toll of opioid dependence: A research report on the possible role of Toll-like receptor-4 and related immune markers in opioid dependence. Indian J Psychiatry. 65(6):626-634.

2022

6. Thakur AK, Rana MK, Luthra-Guptasarma M. (2022) Resistance to unfolding by acidic pH and resistance to lysosomal degradation explains disease-association of HLA-B27 subtypes. Int Immunopharmacol. 112:109226. doi: 10.1016/j.intimp.2022.109226.

7. Kapatia G, Kaur S, Kumar S, Laroiya I, Singh G, Sharma M, Bal A, Luthra-Guptasarma M. (2022) Expression of proteinase-activated receptor 2 (PAR2) as a correlate of concern in triple negative breast cancer (TNBC). Applied Immunohistochemistry & Molecular Morphology 30:446-452. doi: 10.1097/PAI.0000000000001025.

8. Mukhtar U, Goyal A, Luthra-Guptasarma M, Gauba K, Kapur A, Thakur AK (2022) Label-free quantitative proteomics reveals molecular correlates of altered biomechanical properties in molar incisor hypomineralization (MIH): an in vitro study. Eur Arch Paediatr Dent. doi: 10.1007/s40368-021-00687-2.

9. Thakur AK, Luthra-Guptasarma M (2022) Differences in Cellular Clearing Mechanisms of Aggregates of Two Subtypes of HLA-B27. Front Immunol. 12:795053. doi: 10.3389/fimmu.2021.795053.

10. Kaushik S, Luthra-Guptasarma M, Prasher D, Dhingra D, Singh N, Kumar A, Sharma SP, Kaur H, Snehi S, Thattaruthody F, Pandav SS (2021) CYP1B1 and MYOC variants in neonatal-onset versus infantile-onset primary congenital glaucoma. Br J Ophthalmol. doi: 10.1136/bjophthalmol-2020-318563.

2021

11. Santra M, Sharma M, Luthra-Guptasarma M (2021) Studies on Vibrio mimicus derived collagenase variants providing insights into critical role(s) played by the FAXWXXT motifs in its collagen-binding domain. Enzyme and Microbial Technology 147doi: 10.1016/j.enzmictec.2021.109779.

12. Santra M, Sharma M, Katoch D, Jain S, Saikia UN, Dogra MR, Luthra-Guptasarma M (2021) Enzymatic vitreolysis using reengineered Vibrio mimicus–derived collagenase. Molecular Vision 27:125-141.

13. Luthra-Guptasarma M, and Guptasarma P (2021) Does chronic inflammation (CHRi) cause acute inflammation (ACUi) to spiral into hyper-inflammation (HYPi) in a manner modulated by diet and the gut microbiome, in severe Covid-19? Bioessays. doi: 10.1002/bies.202000211.

2020

14. Santra M, Sharma M, Katoch D, Jain S, Saikia UN, Dogra MR, Luthra-Guptasarma M (2020) Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents targeting vitreous collagen liquefaction as well as vitreoretinal adhesion. Sci Rep. 10(1):8250. doi: 10.1038/s41598-020-64931-3.

2019

15. Santra M, and Luthra-Guptasarma M (2019) Assaying collagenase activity by specific labeling of freshly generated N-termini with fluorescamine at mildly acidic pH. Int. J. Peptide Res. And Ther. DOI: 10.1007/s10989-019-09885-5.

16. Sharma M, Kumar R, Sharma S, Thomas B, Kapatia G, Singh G, Bal A, Ram J, Bhasin M, Guptasarma P, Luthra-Guptasarma M (2019) Sustained exposure to trypsin causes cells to transition into a state of reversible stemness that is amenable to transdifferentiation. BioRXiv doi: 10.1101/679928.

2018

17. Mehta BB, Tiwari A, Sharma S, Shukla A, Sharma M, Vasishta RK, Sen RK, Sharma A, Luthra-Guptasarma M (2018) Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C: Targeting fibronectin type III repeats of tenascin-C in rheumatoid arthritis. Int Immunopharmacol. 58:15-23.

18. Mehta BB, Sharma S, Vasishta RK, Sen RK, Sharma A, Luthra-Guptasarma M (2018) Blocking Osteopontin-Fibronectin interactions reduce extracellular fibronectin deployment and arthritic immunopathology. Int Immunopharmacol. 55:297-305.

2017

19. Rana M, and Luthra-Guptasarma M (2017) Differences in conformational stability of the two alpha domains of the disease-associated and non-disease-associated subtypes of HLA-B27. International Journal of Biological Macromolecules 94:233-245.

20. Sharma M, Kumar R, Ram J and Luthra-Guptasarma M (2017) Establishment and characterization of a novel Serine Protease Induced Reprograming (SPIR) method with applications in ocular tissue regeneration. Investigative Ophthalmology & Visual Science 58(8):1426-1426.

2016

21. Tiwari A, Kumar R, Ram J, Sharma M, and Luthra-Guptasarma M (2016) Control of fibrotic changes through the synergistic effects of antifibronectin antibody and an RGDS-tagged form of the same antibody. Sci. Rep. 6:30872.

22. Rana M, and Luthra-Guptasarma M (2016) Multi-modal binding of a 'self' peptide by HLA-B*27:04 and B*27:05 allelic variants, but not B*27:09 or B*27:06 variants: Fresh support for some theories explaining differential disease association. The Protein Journal 35(5):346-353.

2015

23. Bhoria P, Sharma S, Varma N, Malhotra P, Varma S, and Luthra-Guptasarma M (2015) Effect of steroids on the activation status of platelets in patients with Immune thrombocytopenia (ITP). Platelets 26(2):119-26.

24. Bhoria P, Sharma S, Varma N, Malhotra P, Varma S, and Luthra-Guptasarma M (2015) Immunodiagnosis of platelet activation in immune thrombocytopenia (ITP) through scFv antibodies cognate to activated GPIIb/IIIa integrins. mAbs 7:1212-20.

2014

25. Mehta BB, Sharma A, Sen RK, and Luthra-Guptasarma M (2014) Characterization of a fully human antibody targeting osteopontin in the context of rheumatoid arthritis. Indian Journal of Rheumatology9 S22.

26. Tiwari A, Ram J, and Luthra-Guptasarma M (2014) Targeting the fibronectin type III repeats in tenascin-C inhibits epithelial-mesenchymal transition in the context of posterior capsular opacification. Invest Ophthalmol Vis Sci. 56:272-83.

27. Sharma M, Tiwari A, Sharma S, Bansal R, Gupta V, Gupta A, and Luthra-Guptasarma M (2014) Pathologic vitreous causes cell line-derived (but not donor-derived) retinal pigment epithelial cells to display PVR-like features in culture. Clinical and Experimental Ophthalmology 42:745-60.

2013

28. Sharma M, Tiwari A, Sharma S, Bhoria P, Gupta V, Gupta A, and Luthra-Guptasarma M (2013) Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin. PLoS ONE 8(7): e69343. doi:10.1371.

29. Luthra-Guptasarma M, Sharma M, Sharma S, Tiwari A, Gupta V, and Gupta A (2013) Immunospecific targeting of fibronectin towards an anti-fibrotic therapy, with special emphasis on proliferative vitreoretinopathy (PVR). Invest Ophthalmol Vis Sci 54: E-Abstract 6261.

2012

30. Khera S, Tiwari A, Srinivasan R, Gupta A, and Luthra-Guptasarma M (2012) Molecular and morphological evidence for cadaver vitreous-stimulated transformation of differentiation-competent retinal pigment epithelial cells into neuron-like cells. Current Eye Research 37:606-16.

2011

31. Negi R, Bhoria P, Pahuja A, Saikia B, Varma N, Malhotra P, Varma S, and Luthra-Guptasarma M (2011) Investigation of the possible association between the HLA antigens and idiopathic thrombocytopenic purpura (ITP). Immunological Investigations 41:117-28.

32. Khera S, Tiwari A, Srinivasan R, Gupta A, and Luthra-Guptasarma M (2011) Expression of Granulocyte colony stimulating factor (GCSF) and its receptor by retinal pigment epithelial cells (RPE): a role in maintaining differentiation-competent state. Current Eye Research 36:469-80.

2010

33. Arora SK, Sharma R, Kaur G, Bhoria P, Sharma M, and Luthra-Guptasarma M (2010) Towards an indirect screening technique facilitating detection of cellular populations bearing specific cell-surface markers. Biotech Progress 26:1544-50.

34. Luthra-Guptasarma M, and Guptasarma P (2010) Metal-catalyzed proteolysis, conformational antigenicity, photosensitized oxidation, and electrical dysfunction explain the pathogenicity of protein aggregates. Medical Hypotheses 75:294-8.

2009

35. Sharma M, and Luthra-Guptasarma M (2009) Degradation of proteins upon storage at near-neutral pH: Indications of a proteolytic/gelatinolytic activity associated with aggregates. Biochem. Biophys. Acta: General Subjects 1790:1282-94.

2008

36. Verma A, Sharma S, Ganguly NK, Majumdar S, Guptasarma P, and Luthra-Guptasarma M (2008) Identification and characterization of a spontaneously aggregating amyloid-forming variant of human PrP(90-231) through phage-display screening of variants randomized between residues 101-112. Int. J. Biochem. Cell Biol. 40:663-76.

2007

37. Sharma R, Vasishta RK, Sen RK, and Luthra-Guptasarma M (2007) Refolding of HLA-B27 heavy chains in the absence of β2m yields stable high molecular weight (HMW) protein forms displaying native-like as well as non-native-like conformational features: Implications for autoimmune disease. Biochem. Biophys. Acta (Molecular Basis of Disease) 1772:1258-69.

2004

38. Luthra-Guptasarma M, and Singh B (2004). HLA-B27 lacking associated beta 2-microglobulin rearranges to auto-display or cross-display residues 169-181: a novel molecular mechanism for spondyloarthropathies. FEBS Letters, 575/1-3, 1-8.

2002

39. Maiti S, Luthra-Guptasarma M, and Guptasarma P (2002) Phenomenological perspectives on the folding of β/α- barrel domains through the modular formation and assembly of smaller structural elements. IUBMB Life 54(4):213-221.

1996

40. Luthra-Guptasarma M, Woolfson DN, and Evans PA (1996) Studies on the folding of a redesigned form of the small beta sheet protein, tendamistat. In Abstracts of Proceedings of the International Conference on Protein Folding and Design, Fogarty Centre, NIH, Bethesda, 23-26th April.

1994

41. Luthra M, Ranganathan D, Ranganathan S, and Balasubramanian D (1994) Racemization of Tyrosine in the insoluble protein fraction of brunescent ageing human lenses. Journal of Biological Chemistry 269:22678-22682.

42. Luthra M, Ranganathan D, Ranganathan S, and Balasubramanian D (1994) Protein-associated pigments that accumulate in the brunescent eye lens: identification of a quinoline derivative. FEBS Letters 349:39-44.

43. Shalini VK, Luthra M, Srinivas L, Rao SHN, Basti S, Reddy M, and Balasubramanian D (1994) Oxidative damage to the eye lens caused by cigarette smoke and fuel smoke condensates. Indian Journal of Biochemistry and Biophysics 31:261-266.

1993

44. Luthra M, Balasubramanian D. (1993). Non-enzymatic glycation alters protein structure and stability: a study of two eye lens crystallins. Journal of Biological Chemistry, 268, 18119-18127.

45. Balasubramanian D, Shalini VK, Luthra M, Rao SHN, Basti S, and Reddy M (1993). Molecular epidemiology of the smoke-cataract connection: oxidant stress mechanism. Investigative Ophthalmology and Visual Sciences, 34, pp 1297.

1992

46.Luthra M, and Balasubramanian D (1992). 3-Hydroxykynurenine and 3-Hydroxyanthranilic acid may act as endogenous antioxidants in the eye lens. Experimental Eye Research, 55, 641-643.

47. Balasubramanian D, Guptasarma P, and Luthra M (1992). In situ photoreactions of proteins in spectrometers leading to variations in signal intensities. Journal of the American Chemical Society, 114,1877-1878.

1991

48. Luthra M, Sundari C, Guptasarma P, and Balasubramanian D (1991). Crystallin structure and eye lens function. In Molecular Conformations and Biological Interactions (eds P.Balaram and S. Ramaseshan) Indian Academy of Sciences pp 281-293.